Intracellular Domains of NMDA Receptor Subtypes Are Determinants for Long-Term Potentiation Induction

@article{Khr2003IntracellularDO,
  title={Intracellular Domains of NMDA Receptor Subtypes Are Determinants for Long-Term Potentiation Induction},
  author={Georg K{\"o}hr and Vidar R. Jensen and Helmut Joachim Koester and Andr{\'e} L. A. Mihaljevic and Jo Kristian Utvik and Ane Kvello and Ole Petter Ottersen and P. H. Seeburg and Rolf Sprengel and {\O}ivind Hvalby},
  journal={The Journal of Neuroscience},
  year={2003},
  volume={23},
  pages={10791 - 10799}
}
NMDA receptors (NMDARs) are essential for modulating synaptic strength at central synapses. At hippocampal CA3-to-CA1 synapses of adult mice, different NMDAR subtypes with distinct functionality assemble from NR1 with NR2A and/or NR2B subunits. Here we investigated the role of these NMDA receptor subtypes in long-term potentiation (LTP) induction. Because of the higher NR2B contribution in the young hippocampus, LTP of extracellular field potentials could be enhanced by repeated tetanic… 

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