Intracellular Delivery of Short Interfering RNA in Rat Organ of Corti Using a Cell-penetrating Peptide PepFect6

Abstract

RNA interference (RNAi) using short interfering RNA (siRNA) is an attractive therapeutic approach for treatment of dominant-negative mutations. Some rare missense dominant-negative mutations lead to congenital-hearing impairments. A variety of viral vectors have been tested with variable efficacy for modulating gene expression in inner ear. However, there… (More)
DOI: 10.1038/mtna.2012.50

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@inproceedings{DashWagh2012IntracellularDO, title={Intracellular Delivery of Short Interfering RNA in Rat Organ of Corti Using a Cell-penetrating Peptide PepFect6}, author={Suvarna Dash-Wagh and Stefan Jacob and Staffan Lindberg and Anders Fridberger and {\"U}lo Langel and Mats Ulfendahl}, booktitle={Molecular therapy. Nucleic acids}, year={2012} }