Intracellular Delivery of Saquinavir in Biodegradable Polymeric Nanoparticles for HIV/AIDS

  title={Intracellular Delivery of Saquinavir in Biodegradable Polymeric Nanoparticles for HIV/AIDS},
  author={Lipa K. Shah and Mansoor M Amiji},
  journal={Pharmaceutical Research},
This study aims at developing poly(ethylene oxide)-modified poly(epsilon-caprolactone) (PEO-PCL) nanoparticulate system as an intracellular delivery vehicle for saquinavir, an anti-HIV protease inhibitor. Saquinavir-loaded PEO-PCL nanoparticles were prepared by a solvent displacement process. The formed nanoparticles were characterized for size, surface charge, and surface presence of PEO chains. Cellular uptake and distribution of the nanoparticle was examined in THP-1 human monocyte… CONTINUE READING
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