Intracellular Chloride Concentration Changes Modulate IL-1β Expression and Secretion in Human Bronchial Epithelial Cultured Cells.

@article{Clauzure2017IntracellularCC,
  title={Intracellular Chloride Concentration Changes Modulate IL-1β Expression and Secretion in Human Bronchial Epithelial Cultured Cells.},
  author={Mari{\'a}ngeles Clauzure and {\'A}ngel Gabriel Valdivieso and Mar{\'i}a Macarena Massip-Copiz and Consuelo Mori and Andrea V. Dugour and Juan M. Figueroa and Tom{\'a}s A Santa-Coloma},
  journal={Journal of cellular biochemistry},
  year={2017},
  volume={118 8},
  pages={2131-2140}
}
Cystic fibrosis (CF) is caused by mutations in the CFTR gene, which encodes a cAMP-regulated chloride channel. Several cellular functions are altered in CF cells. However, it is not clear how the CFTR failure induces those alterations. We have found previously several genes differentially expressed in CF cells, including c-Src, MUC1, MTND4, and CISD1 (CFTR-dependent genes). Recently, we also reported the existence of several chloride-dependent genes, among them GLRX5 and RPS27. Here, varying… CONTINUE READING
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