Intracellular Calcium and Protein Kinase C Mediate Expression of Receptor Activator of Nuclear Factor-κB Ligand and Osteoprotegerin in Osteoblasts.

Abstract

Receptor activator of nuclear factor-kB ligand (RANKL) and osteoprotegerin (OPG) produced by osteoblasts/stromal cells are involved as positive and negative regulators in osteoclast formation. Three independent signals have been proposed to induce RANKL expression in osteoblasts/stromal cells: vitamin D receptor-, cAMP-, and gp130-mediated signals. We… (More)
DOI: 10.1210/endo.141.12.7852

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