Intracellular Ca2+ stores of T lymphocytes: changes induced by in vitro and in vivo activation.

@article{Clementi1994IntracellularCS,
  title={Intracellular Ca2+ stores of T lymphocytes: changes induced by in vitro and in vivo activation.},
  author={Emilio Clementi and Gianvito Martino and Luigi Grimaldi and Elena Marta Brambilla and Jacopo Meldolesi},
  journal={European journal of immunology},
  year={1994},
  volume={24 6},
  pages={1365-71}
}
Intracellular Ca2+ stores were investigated in resting and activated splenic T lymphocytes from Lewis rats. Activation was obtained either in vitro (spleen cells isolated from "naive" rats exposed to concanavalin A for 24 h) or in vivo (spleen cells from rats with fully developed symptoms of experimental allergic encephalomyelitis). In both experimental conditions several changes of Ca2+ homeostasis were observed with respect to resting lymphocytes: (1) a threefold increase of the total… CONTINUE READING