Intracellular Ca2+ pools in Jurkat T-lymphocytes.

  title={Intracellular Ca2+ pools in Jurkat T-lymphocytes.},
  author={Andreas H. Guse and Edith A. Roth and Frank Emmrich},
  journal={The Biochemical journal},
  volume={291 ( Pt 2)},
Jurkat T-lymphocytes comprise at least four intracellular Ca2+ pools. Pool I was agonist-sensitive and contained 23 +/- 8% (n = 18) of the total Ca(2+)-storage capacity, as shown in intact cells in the presence of EGTA. The time courses of the agonist-induced formation of Ins(1,4,5)P3 and of the Ca2+ release from pool I were nearly superimposable, indicating that the agonist-sensitive pool I is emptied by Ins(1,4,5)P3. Likewise, in permeabilized cells, the size of the Ins(1,4,5)P3-sensitive Ca2… CONTINUE READING
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