Intracellular Ca2+ mediates lipoxygenase-induced proliferation of U-373 MG human astrocytoma cells

@article{Kim1998IntracellularCM,
  title={Intracellular Ca2+ mediates lipoxygenase-induced proliferation of U-373 MG human astrocytoma cells},
  author={J. A. Kim and Yat Joong Chung and Y. S. Lee},
  journal={Archives of Pharmacal Research},
  year={1998},
  volume={21},
  pages={664-670}
}
The role of intracellular Ca2+ in the regulation of tumor cell proliferation by products of arachidonic acid (AA) metabolism was investigated using U-373 MG human astrocytoma cells. Treatment with nordihydroguaiaretic acid (NDGA), a lipoxygenase (LOX) inhibitor, or caffeic acid (CA), a specific 5-LOX inhibitor, suppressed proliferation of the tumor cells in a dose-dependent manner. However, indomethacin (Indo), a cyclooxygenase (COX) inhibitor, did not significantly alter proliferation of the… 

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