Intracellular Ca2+ homeostasis and aggregation in platelets are impaired by ethanol through the generation of H2O2 and oxidation of sulphydryl groups.

@article{Rosado2006IntracellularCH,
  title={Intracellular Ca2+ homeostasis and aggregation in platelets are impaired by ethanol through the generation of H2O2 and oxidation of sulphydryl groups.},
  author={Juan Antonio Rosado and Ana M Nuñez and Jos{\'e} Javier L{\'o}pez and Jos{\'e} Antonio Pariente and Gin{\'e}s M Salido},
  journal={Archives of biochemistry and biophysics},
  year={2006},
  volume={452 1},
  pages={
          9-16
        }
}
  • Juan Antonio Rosado, Ana M Nuñez, +2 authors Ginés M Salido
  • Published 2006
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
  • The mechanisms involved in the effect of ethanol on Ca2+ entry and aggregability have been investigated in human platelets in order to shed new light on the pathogenesis of alcohol consumption. Ethanol (50 mM) induced H2O2 production in platelets by Ca2+-dependent and independent mechanisms. Ca2+ entry induced by ethanol was impaired by catalase. Ethanol reduced SOCE mediated by depletion of the 2,5-di-(tert-butyl)-1,4-hydroquinone (TBHQ)-sensitive acidic stores but enhances SOCE regulated by… CONTINUE READING