Intracellular Ca2+ and cell injury: a paradoxical role of Ca2+ in complement membrane attack.

@article{Morgan1986IntracellularCA,
  title={Intracellular Ca2+ and cell injury: a paradoxical role of Ca2+ in complement membrane attack.},
  author={B. Paul Morgan and J Paul Luzio and Anthony K. Campbell},
  journal={Cell calcium},
  year={1986},
  volume={7 5-6},
  pages={399-411}
}
Disturbances in intracellular Ca2+ are known to be important in cell injury caused by a wide range of toxic factors. The complement system is a major effector of immune damage in vivo, and is known to be involved in the pathogenesis of many immune diseases. We present here evidence that the potentially lethal membrane attack complex of complement causes a rapid increase in intracellular free Ca2+ concentration before any other detectable biochemical changes in the cell. In nucleated cells the… CONTINUE READING
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