Intracellular Ca2+ Oscillations, a Potential Pacemaking Mechanism in Early Embryonic Heart Cells

@article{Sasse2007IntracellularCO,
  title={Intracellular Ca2+ Oscillations, a Potential Pacemaking Mechanism in Early Embryonic Heart Cells},
  author={Philipp Sasse and Jianbao Zhang and Lars Cleemann and Martin Morad and J{\"u}rgen Hescheler and Bernd K Fleischmann},
  journal={The Journal of General Physiology},
  year={2007},
  volume={130},
  pages={133 - 144}
}
Early (E9.5-E11.5) embryonic heart cells beat spontaneously, even though the adult pacemaking mechanisms are not yet fully established. Here we show that in isolated murine early embryonic cardiomyocytes periodic oscillations of cytosolic Ca(2+) occur and that these induce contractions. The Ca(2+) oscillations originate from the sarcoplasmic reticulum and are dependent on the IP(3) and the ryanodine receptor. The Ca(2+) oscillations activate the Na(+)-Ca(2+) exchanger, giving rise to… CONTINUE READING

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