Intracellular Ca(2+) signaling is required for neurotrophin-induced potentiation in the adult rat hippocampus.


Recent studies have demonstrated the importance of neurotrophin function in adult synaptic plasticity. In an effort to characterize the intracellular signaling pathways that couple Trk receptor activation to the final physiological effects of neurotrophins, we have examined the role of intracellular calcium rises in neurotrophin-induced synaptic enhancement… (More)