Intracellular Ca(2+) release from endoplasmic reticulum regulates slow wave currents and pacemaker activity of interstitial cells of Cajal.

@article{Zhu2015IntracellularCR,
  title={Intracellular Ca(2+) release from endoplasmic reticulum regulates slow wave currents and pacemaker activity of interstitial cells of Cajal.},
  author={Mei Zhu and Tae Sik Sung and Kate E O'Driscoll and Sang Don Koh and Kenton M. Sanders},
  journal={American journal of physiology. Cell physiology},
  year={2015},
  volume={308 8},
  pages={C608-20}
}
Interstitial cells of Cajal (ICC) provide pacemaker activity in gastrointestinal muscles that underlies segmental and peristaltic contractions. ICC generate electrical slow waves that are due to large-amplitude inward currents resulting from anoctamin 1 (ANO1) channels, which are Ca(2+)-activated Cl(-) channels. We investigated the hypothesis that the Ca(2+) responsible for the stochastic activation of ANO1 channels during spontaneous transient inward currents (STICs) and synchronized… CONTINUE READING
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