Intracellular Adenosine Triphosphate Deprivation through Lanthanide-Doped Nanoparticles.

  title={Intracellular Adenosine Triphosphate Deprivation through Lanthanide-Doped Nanoparticles.},
  author={Jing Tian and Xiao Zeng and Xiaoji Xie and Sanyang Han and Oi-Wah Liew and Y Chen and Lianhui Wang and Xiaogang Liu},
  journal={Journal of the American Chemical Society},
  volume={137 20},
Growing interest in lanthanide-doped nanoparticles for biological and medical uses has brought particular attention to their safety concerns. However, the intrinsic toxicity of this new class of optical nanomaterials in biological systems has not been fully evaluated. In this work, we systematically evaluate the long-term cytotoxicity of lanthanide-doped nanoparticles (NaGdF4 and NaYF4) to HeLa cells by monitoring cell viability (mitochondrial activity), adenosine triphosphate (ATP) level, and… CONTINUE READING
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