Intracellular ATP binding is required to activate the slowly activating K+ channel I(Ks).

@article{Li2013IntracellularAB,
  title={Intracellular ATP binding is required to activate the slowly activating K+ channel I(Ks).},
  author={Yang Li and Junyuan Gao and Zhongju Lu and Kelli McFarland and Jingyi Shi and Kevin Bock and Ira S. Cohen and Jianmin Cui},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 47},
  pages={18922-7}
}
Gating of ion channels by ligands is fundamental to cellular function, and ATP serves as both an energy source and a signaling molecule that modulates ion channel and transporter functions. The slowly activating K(+) channel I(Ks) in cardiac myocytes is formed by KCNQ1 and KCNE1 subunits that conduct K(+) to repolarize the action potential. Here we show that intracellular ATP activates heterologously coexpressed KCNQ1 and KCNE1 as well as I(Ks) in cardiac myocytes by directly binding to the C… CONTINUE READING
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Molecular mechanisms of BK channel activation

  • GR Tanner, A Lutas, Martínez-François, G Yellen
  • Cell Mol Life Sci
  • 2009

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