Intracellular, intercellular, and stromal invasion of gastric mucosa, preneoplastic lesions, and cancer by Helicobacter pylori.

@article{Necchi2007IntracellularIA,
  title={Intracellular, intercellular, and stromal invasion of gastric mucosa, preneoplastic lesions, and cancer by Helicobacter pylori.},
  author={Vittorio Necchi and Maria Candusso and Francesca Tava and Ombretta Luinetti and Ulderico Ventura and R Fiocca and Vittorio Ricci and Enrico Solcia},
  journal={Gastroenterology},
  year={2007},
  volume={132 3},
  pages={1009-23}
}
BACKGROUND AND AIMS It is not clear how Helicobacter pylori, an apparently extracellular pathogen colonizing the luminal side of the gastric epithelium, invariably causes an immune-inflammatory response on the stromal side of the mucosa. Penetration of H pylori into epithelial cell lines and its interaction with immune-inflammatory cells have been documented in vitro. Several investigations also showed in vivo bacterial penetration into the epithelium up to the lamina propria; however, the… CONTINUE READING