Intracavitary bleomycin in the management of malignant effusions.

@article{Paladine1976IntracavitaryBI,
  title={Intracavitary bleomycin in the management of malignant effusions.},
  author={W J Paladine and Thomas J. Cunningham and R. W. Sponzo and M A Donavan and Karen Olson and John Horton},
  journal={Cancer},
  year={1976},
  volume={38 5},
  pages={1903-8}
}
Instilled bleomycin and thoracostomy were utilized in 38 patients with malignant pleural effusions; the therapy produced a complete or partial response rate of 63%. Toxicity was minimal. In patients with intraperitoneal effusions, bleomycin instillation after drainage produced a complete or partial response in 36%. One patient had severe hypotension and fever. Patients with ovarian and breast carcinoma responded best, among them, effusions were controlled in greater that 70%. Because of its low… CONTINUE READING

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