Intracarotid histamine infusion increases blood tumour permeability in RG2 glioma.

@article{Inamura1994IntracarotidHI,
  title={Intracarotid histamine infusion increases blood tumour permeability in RG2 glioma.},
  author={Takanori Inamura and Tomojiro Nomura and Kiyonobu Ikezaki and Masashi Fukui and G P{\"o}llinger and Keith L. Black},
  journal={Neurological research},
  year={1994},
  volume={16 2},
  pages={125-8}
}
Histamine will alter blood flow and permeability in systemic and cerebral vessels. We reported that intracarotid infusion of histamine selectively increased the blood flow in experimental brain tumours and caused extravassation of Evans blue within tumours. In this study, the effects of histamine on tumour and brain capillary permeability were quantified using autoradiography. RG2 glioma cells were implanted in female Wistar rats. Seven days after implantation, either low doses of histamine (1… CONTINUE READING

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