Intracarotid Etomidate is a Safe Alternative to Sodium Amobarbital for the Wada Test

  title={Intracarotid Etomidate is a Safe Alternative to Sodium Amobarbital for the Wada Test},
  author={Ramamani Mariappan and Pirjo H. Manninen and Mary Pat McAndrews and Melanie Cohn and Peter Tai and Taufik A. Valiante and Lashmi Venkatraghavan},
  journal={Journal of Neurosurgical Anesthesiology},
Background: The Wada procedure (the intracarotid amobarbital procedure) has been used widely to evaluate the hemispheric dominance of language and memory before temporal lobe surgery in patients with medically refractory seizures. Because of repeated shortage of sodium amobarbital, attempts have been made to find a suitable alternative to sodium amobarbital. The aim of our study was to review our experience with the use of etomidate as an alternative to sodium amobarbital for Wada testing in… 
Intracarotid Etomidate Decreases the Interhemispheric Synchronization in Electroencephalogram (EEG) During the Wada Test
The study showed that the EEG effects of intracarotid ipsilateral injection of etomidate is not uniform in both hemispheres, and decrease in the interhemispheric synchronization of delta waves might serve as an indicator of ipsilaterally effect of Etomidate on the brain.
Tolerability of propofol in Wada testing
It is found that propofol is well tolerable for the Wada test, with minimally significant complications, although blood pressure should be closely monitored.
Experience of adverse events with cerebral propofol testing in patients with drug resistant epilepsy
Most of the adverse events occurring during the Wada test with propofol were mild and short-lived, and this procedure can be perceived as a good method for assessing language and memory in a fraction of the epilepsy surgery candidates.
Intra-arterial etomidate for provocative testing in embolization procedure for cerebral arteriovenous malformation.
Therapeutic hypothermia after perioperative cardiac arrest in cardiac surgical patients and strategies for improving survival after inhospital cardiac arrest are recommended.
Neuroanesthesiology Update
We reviewed manuscripts published in 2016 that are related to the care of neurosurgical patients or the perioperative care of patients with neurological diseases. We address the broad categories of
Assessment of Potential Long Term Health Effects on Army Human Test Subjects of Relevant Biological and Chemical Agents, Drugs, Medications and Substances
Abstract : Between 1954 and 1975, more than 12,000 men entering or in military service in the United States (US) served as medical research volunteers for the countrys biological and chemical warfare


Etomidate speech and memory test (eSAM)
Etomidate is a viable alternative to amobarbital, and its administration by bolus followed by infusion offers an improvement over the traditional intracarotid amobarBital procedure.
Alternatives to Sodium Amobarbital in the Wada Test
Methohexital, pentobarbital, etomidate, and propofol are viable alternatives to sodium amobarBital for use in the Wada test, but each has shortcomings.
Wada test using secobarbital sodium (Ional) to determine language dominance
Secobarbital sodium is proposed as a safe and reliable alternative to sodium amobarbitals used in the Wada test to determine language dominance and its efficacy is reported.
Can pentobarbital replace amobarbital in the Wada test?
Intracarotid propofol test for speech and memory dominance in man
With direct intracarotid propofol injection, the Wada test was satisfactorily performed in all 12 patients and 2 more patients with left-handedness or with different injection dose for each side without any complications.