Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis

  title={Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis},
  author={Jay R. Hove and Reinhard W K{\"o}ster and Arian S. Forouhar and Gabriel Acevedo-Bolton and Scott E. Fraser and Morteza Gharib},
The pattern of blood flow in the developing heart has long been proposed to play a significant role in cardiac morphogenesis. In response to flow-induced forces, cultured cardiac endothelial cells rearrange their cytoskeletal structure and change their gene expression profiles. To link such in vitro data to the intact heart, we performed quantitative in vivo analyses of intracardiac flow forces in zebrafish embryos. Using in vivo imaging, here we show the presence of high-shear, vortical flow… CONTINUE READING
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