Intracapillary leucocyte accumulation as a novel antihaemorrhagic mechanism in acute pancreatitis in mice.

@article{Ryschich2009IntracapillaryLA,
  title={Intracapillary leucocyte accumulation as a novel antihaemorrhagic mechanism in acute pancreatitis in mice.},
  author={Eduard Ryschich and Vachtang Kerkadze and Olegas Deduchovas and Olga Salnikova and Audrius Parseliunas and Angela M{\"a}rten and W. Hartwig and Markus Sperandio and Joachim Schmidt},
  journal={Gut},
  year={2009},
  volume={58 11},
  pages={1508-16}
}
BACKGROUND Pancreatic infiltration by leucocytes represents a hallmark in acute pancreatitis. Although leucocytes play an active role in the pathophysiology of this disease, the relation between leucocyte activation, microvascular injury and haemorrhage has not been adequately addressed. METHODS We investigated intrapancreatic leucocyte migration, leucocyte extravasation and pancreatic microperfusion in different models of oedematous and necrotising acute pancreatitis in lys-EGFP-ki mice… CONTINUE READING

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