Intrabodies against the Polysialyltransferases ST8SiaII and ST8SiaIV inhibit Polysialylation of NCAM in rhabdomyosarcoma tumor cells

Abstract

BACKGROUND Polysialic acid (polySia) is a carbohydrate modification of the neural cell adhesion molecule (NCAM), which is implicated in neural differentiation and plays an important role in tumor development and metastasis. Polysialylation of NCAM is mediated by two Golgi-resident polysialyltransferases (polyST) ST8SiaII and ST8SiaIV. Intracellular… (More)
DOI: 10.1186/s12896-017-0360-7

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@inproceedings{Somplatzki2017IntrabodiesAT, title={Intrabodies against the Polysialyltransferases ST8SiaII and ST8SiaIV inhibit Polysialylation of NCAM in rhabdomyosarcoma tumor cells}, author={Stefan Somplatzki and Martina M{\"u}hlenhoff and Andrea Kr{\"o}ger and Rita Gerardy-Schahn and Thomas B{\"o}ldicke}, booktitle={BMC biotechnology}, year={2017} }