Intraarticular minocycline injection in experimental synovitis

  title={Intraarticular minocycline injection in experimental synovitis},
  author={Prof. A. Weinberger and Tuvia Ben-Gal and Pepi Roizman and Armand Abramovici},
  journal={Clinical Rheumatology},
Minocycline, a semi-synthetic tetracycline, was injected into one hind joint of twenty-two rabbits with zymosan-induced arthritis, while the contralateral joint served as a control. A local inflammatory reaction was observed a few days after the zymosan injection. Most clinical parameters such as knee diameter, systemic temperature, sedimentation rate and blood cell count did not change throughout the experiment both in control and minocycline treated rabbits. However, the zymosan platelet… CONTINUE READING

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Suppression of collagen and adjuvant arthritis by a tetracycline

EC. Breedvetd, J. M. O'Brien, C. E. Brinckerhoff, D. E. Trentham
Arthritis Rheum • 1988

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