Intra-tumor Genetic Heterogeneity and Mortality in Head and Neck Cancer: Analysis of Data from The Cancer Genome Atlas

@inproceedings{Mroz2015IntratumorGH,
  title={Intra-tumor Genetic Heterogeneity and Mortality in Head and Neck Cancer: Analysis of Data from The Cancer Genome Atlas},
  author={Edmund A. Mroz and Aaron M. Tward and Rebecca J. Hammon and Yin Ren and James W. Rocco},
  booktitle={PLoS medicine},
  year={2015}
}
BACKGROUND Although the involvement of intra-tumor genetic heterogeneity in tumor progression, treatment resistance, and metastasis is established, genetic heterogeneity is seldom examined in clinical trials or practice. Many studies of heterogeneity have had prespecified markers for tumor subpopulations, limiting their generalizability, or have involved… CONTINUE READING