Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification.

@article{Eladad2005IntranuclearTO,
  title={Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification.},
  author={Sonia Eladad and T Ye and Peng Hu and Margaret A. Leversha and Sergey Beresten and Michael J Matunis and Nathan A Ellis},
  journal={Human molecular genetics},
  year={2005},
  volume={14 10},
  pages={
          1351-65
        }
}
The Bloom syndrome gene, BLM, encodes a RecQ DNA helicase that when absent from the cell results in genomic instability and cancer predisposition. We show here that BLM is a substrate for small ubiquitin-like modifier (SUMO) modification, with lysines at K317, K331, K334 and K347 being preferred sites of modification. Unlike normal BLM, a double mutant BLM protein with lysine to arginine substitutions at residues 317 and 331 was not modified by SUMO, and it failed to localize efficiently to the… CONTINUE READING

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