Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress.

@article{Du2003IntramitochondrialPC,
  title={Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress.},
  author={Lina Du and Xiaopeng Zhang and Y. Y. Han and Nancy A. Burke and Patrick M Kochanek and Simon C. Watkins and Steven H Graham and Joseph Carcillo and Csaba Szab{\'o} and Robert S B Clark},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 20},
  pages={18426-33}
}
Poly(ADP-ribosylation), primarily via poly(ADP-ribose) polymerase-1 (PARP-1), is a pluripotent cellular process important for maintenance of genomic integrity and RNA transcription in cells. However, during conditions of oxidative stress and energy depletion, poly(ADP-ribosylation) paradoxically contributes to mitochondrial failure and cell death. Although it has been presumed that poly(ADP-ribosylation) within the nucleus mediates this pathologic process, PARP-1 and other poly(ADP… CONTINUE READING
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