Intra-mitochondrial poly(ADP-ribosyl)ation: potential role for alpha-ketoglutarate dehydrogenase.

@article{Pankotai2009IntramitochondrialPP,
  title={Intra-mitochondrial poly(ADP-ribosyl)ation: potential role for alpha-ketoglutarate dehydrogenase.},
  author={Eszter Pankotai and Zsombor Lacza and Marianna Mur{\'a}nyi and Csaba Szab{\'o}},
  journal={Mitochondrion},
  year={2009},
  volume={9 2},
  pages={159-64}
}
Poly(ADP-ribose) polymerase (PARP) is an intracellular enzyme involved in DNA repair and in building poly-ADP-ribose polymers on nuclear proteins using NAD(+). While the majority of PARP resides in the nucleus, several studies indicated that PARP may also be located in the cytosol or in the mitochondrial matrix. In this study we found several poly-ADP-ribosylated proteins in isolated rat liver mitochondria following hydrogen peroxide (H(2)O(2)) or nitric oxide donor treatment. Protein poly-ADP… CONTINUE READING
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