Intra-islet regulation of hormone secretion by glucagon-like peptide-1-(7--36) amide.

  title={Intra-islet regulation of hormone secretion by glucagon-like peptide-1-(7--36) amide.},
  author={R S Heller and Gregory W. Aponte},
  journal={The American journal of physiology},
  volume={269 6 Pt 1},
Glucagon-like peptide (GLP)-1-(7--36) amide, a peptide product of the posttranslational processing of pancreatic and intestinal proglucagon, has been shown to regulate insulin secretion. Monoclonal antibodies to glucagon and GLP-1-(7--36) amide were generated to localize GLP-1-(7--36) amide in the pancreatic islets by immunocytochemistry and radioimmunoassay. GLP-1-(7--36) amide immunoreactivity was found in some, but not all, glucagon-containing alpha-cells. Displaceable receptor binding for… CONTINUE READING

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