Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression.

@article{Graham2012IntraisletPO,
  title={Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression.},
  author={Kate L. Graham and Balasubramanian Krishnamurthy and Stacey Fynch and Rochelle Ayala-Perez and Robyn Maree Slattery and Pere Santamaria and Helen E. Thomas and Thomas W. H. Kay},
  journal={European journal of immunology},
  year={2012},
  volume={42 7},
  pages={1717-22}
}
Infiltration of pancreatic islets by immune cells, termed insulitis, increases progressively once it begins and leads to clinical type 1 diabetes. But even after diagnosis some islets remain unaffected and infiltration is patchy rather than uniform. Traffic of autoreactive T cells into the pancreas is likely to contribute to insulitis progression but it could also depend on T-cell proliferation within islets. This study utilizes transgenic NOD mice to assess the relative contributions of these… CONTINUE READING