Intra-individual comparison of the human biodistribution and dosimetry of the D and L isomers of 2-[123I]iodo-phenylalanine.

@article{Bauwens2007IntraindividualCO,
  title={Intra-individual comparison of the human biodistribution and dosimetry of the D and L isomers of 2-[123I]iodo-phenylalanine.},
  author={Matthias Bauwens and Marleen Keyaerts and Tony Lahoutte and Ken Kersemans and Vicky Caveliers and Axel Bossuyt and John Mertens},
  journal={Nuclear medicine communications},
  year={2007},
  volume={28 10},
  pages={823-8}
}
PURPOSE Several authors have shown in animal studies that D-enantiomeric amino acid analogues can have better tumour imaging properties compared to their L-analogues. In our group, the D and L isomers of 2-[I]iodo-phenylalanine were identified as tumour-specific tracers in rat and mouse tumour models, with an advantage for the D-isomer. Here we compare, intra-individually, the normal biodistribution and dosimetry of both tracers in healthy human subjects. METHODS Five male volunteers received… CONTINUE READING

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