Intra-follicular activin availability is altered in prenatally-androgenized lambs

@article{West2001IntrafollicularAA,
  title={Intra-follicular activin availability is altered in prenatally-androgenized lambs},
  author={Christine M. West and Douglas L. Foster and Neil Price Evans and Jane Elizabeth Robinson and Vasantha Padmanabhan},
  journal={Molecular and Cellular Endocrinology},
  year={2001},
  volume={185},
  pages={51-59}
}
Prenatal exposure of sheep to testosterone (T) disrupts ovarian cyclicity and leads to anovulation in adulthood. We propose that the disruption of ovarian function in prenatally-androgenized sheep is mediated via follicular defects stemming from reduced intrafollicular activin availability/action. The intra-follicular activin availability/action that facilitates follicular development is dictated by the relative proportions of activins, inhibins (antagonists of activin action) and follistatins… CONTINUE READING
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