The difference in intraocular pressure (IOP) between the highest and lowest measurements on an eye with non-contact tonometry (the range) has been reported to be less than 4 mmHg in most normals. The range of IOP to be expected with the Keeler Pulsair in normals over the age of 50 years was determined by analysing the results of IOP recordings on 741 normal individuals. Between 56% and 62% of eyes recorded a range >4 mmHg and between 4% and 8% a range >10 mmHg when four pulses per eye were used. Population pulse profile analysis indicated that this was not due to an erroneously high first pulse in a set of four, and that IOP asymmetry previously reported when screening females is due to a generalised tendency for IOPs in right eyes to measure higher than those recorded in the left. The occurrence of a range of IOP recordings up to 10 mmHg in an eye is relatively common with the Pulsair and individuals undergoing glaucoma screening with this instrument should not be referred purely on the basis of a large IOP range.