Intra-endosomal trafficking mediated by lysobisphosphatidic acid contributes to intracellular release of phosphorothioate-modified antisense oligonucleotides

@inproceedings{Wang2017IntraendosomalTM,
  title={Intra-endosomal trafficking mediated by lysobisphosphatidic acid contributes to intracellular release of phosphorothioate-modified antisense oligonucleotides},
  author={Shiyu Wang and Hong Sun and Michael Tanowitz and Xue-Hai Liang and Stanley T. Crooke},
  booktitle={Nucleic acids research},
  year={2017}
}
Antisense oligonucleotides (ASOs) with phosphorothioate (PS) linkages are broadly used as research tools and therapeutic agents. Chemically modified PS-ASOs can mediate efficient target reduction by site-specific cleavage of RNA through RNase H1. PS-ASOs are known to be internalized via a number of endocytotic pathways and are released from membrane… CONTINUE READING