Intra-cluster recombination and var transcription switches in the antigenic variation of Plasmodium falciparum.

@article{Deitsch1999IntraclusterRA,
  title={Intra-cluster recombination and var transcription switches in the antigenic variation of Plasmodium falciparum.},
  author={Kirk W. Deitsch and A del Pinal and Thomas E Wellems},
  journal={Molecular and biochemical parasitology},
  year={1999},
  volume={101 1-2},
  pages={107-16}
}
Antigenic variation and immune evasion by Plasmodium falciparum parasitized erythrocytes are mediated by expression switches among members of the multicopy var gene family. Here we describe a cluster of var genes on chromosome 12 that showed spontaneous recombination and switches in the transcription of individual genes. The transcription switches were not associated with sequence changes in promoter regions. Transfected episomes containing a luciferase reporter under control of a var promoter… CONTINUE READING

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