Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice.

@article{Saadoun2010IntracerebralIO,
  title={Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice.},
  author={Samira Saadoun and Patrick H. Waters and B. Anthony Bell and A Onodugo Vincent and Alan S Verkman and Marios C Papadopoulos},
  journal={Brain : a journal of neurology},
  year={2010},
  volume={133 Pt 2},
  pages={
          349-61
        }
}

• Samira Saadoun, Patrick H. Waters, +3 authors Marios C Papadopoulos
• Published in Brain : a journal of neurology 2010
• DOI:10.1093/brain/awp309

Neuromyelitis optica is an inflammatory demyelinating disease of the central nervous system associated with autoantibodies against the glial water channel protein aquaporin-4. It has recently been reported that immunoglobulin from neuromyelitis optica patients injected peripherally does not cause lesions in naive rats, but only when pre-existing central nervous system inflammation is present. Here, we investigated whether immunoglobulin G from aquaporin-4-autoantibody-positive neuromyelitis… CONTINUE READING

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