Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice.

  title={Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice.},
  author={S. Saadoun and P. Waters and B. Bell and A. Vincent and A. Verkman and M. Papadopoulos},
  journal={Brain : a journal of neurology},
  volume={133 Pt 2},
  • S. Saadoun, P. Waters, +3 authors M. Papadopoulos
  • Published 2010
  • Medicine
  • Brain : a journal of neurology
  • Neuromyelitis optica is an inflammatory demyelinating disease of the central nervous system associated with autoantibodies against the glial water channel protein aquaporin-4. It has recently been reported that immunoglobulin from neuromyelitis optica patients injected peripherally does not cause lesions in naive rats, but only when pre-existing central nervous system inflammation is present. Here, we investigated whether immunoglobulin G from aquaporin-4-autoantibody-positive neuromyelitis… CONTINUE READING
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