Intra-articular transplantation of atsttrin-transduced mesenchymal stem cells ameliorate osteoarthritis development.

  title={Intra-articular transplantation of atsttrin-transduced mesenchymal stem cells ameliorate osteoarthritis development.},
  author={Qingqing Xia and Shouan Zhu and Yan Wu and Jiaqiu Wang and Youzhi Cai and Pengfei Chen and Jie Li and Boon Chin Heng and Hongwei Ouyang and Ping Jung Lu},
  journal={Stem cells translational medicine},
  volume={4 5},
Osteoarthritis (OA) remains an intractable clinical challenge. Few drugs are available for reversing this degenerative disease, although some promising candidates have performed well in preclinical studies. Tumor necrosis factor α (TNFα) has been identified as a crucial effector modulating OA pathogenesis. This study aimed to investigate the therapeutic effects of Atsttrin, a novel TNFα blocker, on OA treatment. We developed genetically modified mesenchymal stem cells (MSCs) that expressed… CONTINUE READING
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