Intra-articular sodium hyaluronate in osteoarthritis of the knee.

  title={Intra-articular sodium hyaluronate in osteoarthritis of the knee.},
  author={Roy Altman},
  journal={Seminars in arthritis and rheumatism},
  volume={30 2 Suppl 1},
  • Roy Altman
  • Published 2000 in Seminars in arthritis and rheumatism
OBJECTIVES Hyaluronan (HA) has recently been approved in the United States for management of pain in osteoarthritis (OA) of the knee and is the first biological available for use in OA. To better understand the therapeutic role of HA, this review focuses on comparative clinical trial data. METHODS Literature reports of clinical trials comparing HA with placebo, nonsteroidal anti-inflammatory drugs, and intra-articular corticosteroids were reviewed. The pivotal US trial evaluating HA efficacy… CONTINUE READING


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