Intra-articular ozone therapy efficiently attenuates pain in knee osteoarthritic subjects: A systematic review and meta-analysis.

@article{NooriZadeh2019IntraarticularOT,
  title={Intra-articular ozone therapy efficiently attenuates pain in knee osteoarthritic subjects: A systematic review and meta-analysis.},
  author={Ali Noori-Zadeh and Salar Bakhtiyari and Roghayeh Khooz and Karimeh Haghani and Shahram Darabi},
  journal={Complementary therapies in medicine},
  year={2019},
  volume={42},
  pages={
          240-247
        }
}
The effect of intra-articular ozone injection on pain and physical function in knee osteoarthritis: A prospective study
TLDR
This study demonstrates that intra-articular ozone injection treatment provides improvement in pain and physical functionality in osteoarthritis patients and believes that future studies may include AROM as an objective measurement among evaluation methods.
Intraarticular Injections of Ozone Gas in Knee Osteoarthritis
TLDR
The degree of evidence from such studies is so low that ozone should not be recommended for the treatment of KOA, and better designed studies are needed with a greater degree ofEvidence and with a longer follow-up to confirm what current literature reflects: that intraarticular ozone seems to be highlighted pain in the short-term in patients with KOA.
Integration of focal vibration and intra-articular oxygen–ozone therapy in rehabilitation of painful knee osteoarthritis
TLDR
An integrated rehabilitation protocol involving O2O3 injections and mFV for 3 weeks reduces pain, increases autonomy in daily life activities, and strengthens the quadriceps femoris.
COMPARATIVE EVALUATION OF OZONE GAS AND OZONATED WATER AFTER ARTHROCENTESIS IN MANAGEMENT OF TEMPRO MANDIBULAR JOINT INTERNAL DERANGEMENT: A CLINICAL RANDOMIZED CONTROLLED STUDY
  • S. Bakry
  • Medicine
    Egyptian Dental Journal
  • 2022
TLDR
The use of ozone gas injection following arthrocentesis for patients suffering from TMJ internal derangement pain is successful in improving TMJ function and help in reducing pain and assist in better mouth opening as it is simple, safe, effective procedure, minimally invasive and with low risk of infection.
How to Choose Platelet-Rich Plasma or Hyaluronic Acid for the Treatment of Knee Osteoarthritis in Overweight or Obese Patients: A Meta-Analysis
TLDR
For overweight or obese patients with knee OA, intra-articular injection of PRP in a short time was not necessarily superior to HA, but long-term use was better than HA in pain and functional relief.
Symptomatic (Pain and Inflammation) and Disease-Modifying Effect (Minimal Joint Space) of Intra-articular Ozone (O2-O3) in Osteoarthritis of the Knee: a Clinical Case
TLDR
Intra-articular ozone (O2-O3) has shown a symptomatic effect and especially a disease-modifying effect in a patient with knee osteoarthritis, improving pain, function, and rigidity; decreasing inflammation biomarkers (CRP, ESR, and uric acid); and increasing the joint space of the medial component evidenced radiologically.
Intra-articular ozone modulates inflammation, ameliorates pain and rigidity, improves function and has anabolic effect on knee osteoarthritis: a prospective quasi-experimental before-and-after study, 115 patients
TLDR
Intra-articular ozone modulates inflammation, ameliorates pain and rigidity, improves function and has anabolic effect on knee osteoarthritis in 115 patients in a prospective quasi-experimental before-and-after study.
Ozone therapy for musculoskeletal disorders: Current concepts
  • I. Akkawi
  • Medicine
    Acta bio-medica : Atenei Parmensis
  • 2020
TLDR
O2-O3 has been proved to be effective in reducing pain in many musculoskeletal disorders including low back pain, lumbar disk herniation, cervical pain, cervical disk herNiation, failed back surgery syndrome, degenerative spinal disease, knee osteoarthritis, meniscal injuries, sacroiliitis, plantar fasciitis and carpal tunnel syndrome.
Use of hyaluronic acid associated with triamcinolone acetonide or ozone gas in the treatment of induced osteoarthritis in rabbits
TLDR
The intra-articular injection of hyaluronic acid associated with triamcinolone accentuated degenerative joint disease by imaging and macroscopic evaluations, and by histological findings, this treatment and the ozone gas treatment showed similar effects and were inferior to the saline solution.
...
...

References

SHOWING 1-10 OF 21 REFERENCES
Safety of Intra-Articular Oxygen-Ozone Therapy Compared to Intra-ArticularSodium Hyaluronate in Knee Osteoarthritis: A Randomized Single Blind PilotStudy
TLDR
Despite IA administration of O2O3 and hyaluronan are comparable treatments in knee OA both in terms of safety and quality of life improvement, the latter shows longer times of pain reduction.
Comparison between intra-articular ozone and placebo in the treatment of knee osteoarthritis: A randomized, double-blinded, placebo-controlled study
TLDR
The study confirms the efficacy of ozone concerning pain relief, functional improvement, and quality of life in patients with knee osteoarthritis.
Intra-articular ozone or hyaluronic acid injection: Which one is superior in patients with knee osteoarthritis? A 6-month randomized clinical trial
TLDR
Although both ozone and HA can be effectively used for improving function and reducing pain in selected knee OA patients, neither of the two showed any superiority at 6-month follow-up.
Effect of Intraarticular injection of ozone on inflammatory cytokines in knee osteoarthritis
TLDR
Intraarticular Ozone induces significantly longer improvement of pain and disability in knee osteoartherosis compare to steroid injection, and serum inflammatory cytokines are also lower in Ozone group compared to steroid group along with clinical improvements.
Therapeutic Efficacy of Ozone Injection into the Knee for the Osteoarthritis Patient along with Oral Celecoxib and Glucosamine.
TLDR
Intra-articular injection of ozone plus oral celecoxib and glucosamine could significantly decrease pain intensity in patients with mild to moderate Knee Osteoarthritis (KOA), and improve their functional status early than oral cele Coxib and glucose orally.
Intra Articular Ozone Reduces Serum Uric Acid and Improves Pain, Function and Quality of Life in Knee Osteoarthritis Patients: A Before-and-After Study
TLDR
Intra articular ozone is capable of decreasing pain and stiffness and improving function and quality of life, as well as decreasing serum uric acid in knee OA patients.
The Comparison between Two Methods for the Relief of Knee Osteoarthritis Pain: Radiofrequency and Intra-Periarticular Ozone Injection: A Clinical Trial Study
TLDR
Both radiofrequency and intra-periarticular ozone injection have good clinical effects on knee osteoarthritis with superiority of radiofrequency in age above 65 years old.
Osteoarthritis and all-cause mortality in worldwide populations: grading the evidence from a meta-analysis
TLDR
No reliable and confident evidence existed currently in respect of the association between OA and all-cause mortality and the overall GARDE evidence quality was very low, which will lower confidence in taking recommendations.
The effects of ultrasound-guided corticosteroid injection compared to oxygen–ozone (O2–O3) injection in patients with knee osteoarthritis: a randomized controlled trial
TLDR
The study showed that the effects of oxygen–ozone injection last longer than those of steroid injection to the knee joint and both steroid and oxygen-ozone injections are effective in patients with knee osteoarthritis.
The Effects of Prolotherapy With Hypertonic Dextrose Versus Prolozone (Intraarticular Ozone) in Patients With Knee Osteoarthritis
TLDR
Prolotherapy with dextrose and with prolozone result in the same pain relief or functional improvement in patients with mild to moderate KOA.
...
...