Intra-articular injections of high-molecular-weight hyaluronic acid have biphasic effects on joint inflammation and destruction in rat antigen-induced arthritis

@article{Roth2005IntraarticularIO,
  title={Intra-articular injections of high-molecular-weight hyaluronic acid have biphasic effects on joint inflammation and destruction in rat antigen-induced arthritis},
  author={Andreas H. F. J. Roth and Juergen A Mollenhauer and Andreas F Wagner and Ren{\'e}e AE Fuhrmann and Albrecht Straub and Rudolf A. Venbrocks and P. Petrow and Rolf Br{\"a}uer and H. Schubert and J{\"o}rg H Ozegowski and Gundela Peschel and Peter Mueller and Raimund W. Kinne},
  journal={Arthritis Research & Therapy},
  year={2005},
  volume={7},
  pages={R677 - R686}
}
To assess the potential use of hyaluronic acid (HA) as adjuvant therapy in rheumatoid arthritis, the anti-inflammatory and chondroprotective effects of HA were analysed in experimental rat antigen-induced arthritis (AIA). Lewis rats with AIA were subjected to short-term (days 1 and 8, n = 10) or long-term (days 1, 8, 15 and 22, n = 10) intra-articular treatment with microbially manufactured, high-molecular-weight HA (molecular weight, 1.7 x 10(6) Da; 0.5 mg/dose). In both tests, 10 buffer… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Similar Papers

Loading similar papers…