Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: multicenter randomized controlled clinical trial (phase I/II)

@inproceedings{LamoEspinosa2016IntraarticularIO,
  title={Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: multicenter randomized controlled clinical trial (phase I/II)},
  author={Jos{\'e} Mar{\'i}a Lamo-Espinosa and Gonzalo E Mora and Juan Francisco B. Blanco and Froil{\'a}n Granero-Molt{\'o} and Jorge Mar{\'i}a N{\'u}{\~n}ez-C{\'o}rdoba and Carmen S{\'a}nchez-Echenique and Jos{\'e} Mar{\'i}a Bond{\'i}a and Jes{\'u}s D{\'a}maso Aquerreta and Enrique Jos{\'e} Andreu and Enrique Ornilla and Eva Mar{\'i}a Villar{\'o}n and Andr{\'e}s Valent{\'i}-Azc{\'a}rate and Fermin F S{\'a}nchez-Guijo and Mar{\'i}a Consuelo del Ca{\~n}izo and Juan Ram{\'o}n Valent{\'i}-Nin and Felipe Pr{\'o}sper},
  booktitle={Journal of Translational Medicine},
  year={2016}
}
Mesenchymal stromal cells are a promising option to treat knee osteoarthritis. Their safety and usefulness must be confirmed and the optimal dose established. We tested increasing doses of bone marrow mesenchymal stromal cells (BM-MSCs) in combination with hyaluronic acid in a randomized clinical trial. A phase I/II multicenter randomized clinical trial with active control was conducted. Thirty patients diagnosed with knee OA were randomly assigned to intraarticularly administered hyaluronic… CONTINUE READING
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implica‐ tions for research

  • JA Buckwalter, C Saltzman, osteoarthritis Brown T. The impact of
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  • 2016
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