Intra-articular injection of human meniscus stem/progenitor cells promotes meniscus regeneration and ameliorates osteoarthritis through stromal cell-derived factor-1/CXCR4-mediated homing.

@article{Shen2014IntraarticularIO,
  title={Intra-articular injection of human meniscus stem/progenitor cells promotes meniscus regeneration and ameliorates osteoarthritis through stromal cell-derived factor-1/CXCR4-mediated homing.},
  author={Wei-Liang Shen and Jialin Chen and Ting Zhu and Longkun Chen and Wei Zhang and Zhi Fang and Boon Chin Heng and Zi Yin and Xiao Chen and Junfeng Ji and Weishan Chen and Hongwei Ouyang},
  journal={Stem cells translational medicine},
  year={2014},
  volume={3 3},
  pages={
          387-94
        }
}
Meniscus injury is frequently encountered in clinical practice. Current surgical therapy involving partial or complete meniscectomy relieves pain in the short-term but often leads to osteoarthritis (OA) in the long-term. In this study, we report a new strategy of articular cartilage protection by intra-articular injection of novel human meniscus stem/progenitor cells (hMeSPCs). We found that hMeSPCs displayed both mesenchymal stem cell characteristics and high expression levels of collagen II… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Meniscus repair using mesenchymal stem cells – a comprehensive review

Stem Cell Research & Therapy • 2015
View 8 Excerpts
Highly Influenced

Chemokines and inflammation in osteoarthritis: Insights from patients and animal models.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society • 2017

Similar Papers

Loading similar papers…