Intra-articular hyaluronate in experimental rabbit osteoarthritis can prevent changes in cartilage proteoglycan content.

@article{Hulmes2004IntraarticularHI,
  title={Intra-articular hyaluronate in experimental rabbit osteoarthritis can prevent changes in cartilage proteoglycan content.},
  author={David J S Hulmes and Mark E. Marsden and Robin K. Strachan and Ron{\'e}e E. Harvey and Neil McInnes and Dugald Lindsay Gardner},
  journal={Osteoarthritis and cartilage},
  year={2004},
  volume={12 3},
  pages={232-8}
}
OBJECTIVE The purpose of this study was to determine the effects of intra-articular injections of high molecular weight (2000 kDa) sodium hyaluronate (HA) on the progression of articular cartilage degeneration in a rabbit partial medial meniscectomy model of osteoarthritis. DESIGN Six experimental groups included normal, sham operated, and operated and injected animals, the latter injected once-weekly (for two weeks or twelve weeks, beginning four weeks after surgery) with either 1% (w/v) HA… CONTINUE READING