Intra-articular distribution and residence time of Hylan A and B: a study in the goat knee.

@article{Jackson2006IntraarticularDA,
  title={Intra-articular distribution and residence time of Hylan A and B: a study in the goat knee.},
  author={Douglas W Jackson and Timothy M. Simon},
  journal={Osteoarthritis and cartilage},
  year={2006},
  volume={14 12},
  pages={1248-57}
}
OBJECTIVE This study evaluates the viscosupplementation material Hylan A and B in relation to its: (1) joint distribution, residence time and mechanism of removal and/or degradation, and (2) associated synovial fluid leukocyte response, in a goat model. METHOD One green fluorophore was covalently bound to the Hylan A low molecular weight (MW) molecule (viscous fluid fraction) and a second red fluorophore was covalently bound to Hylan B high MW molecule (globule gel-like fraction). Goats were… CONTINUE READING