Intra-articular depot formulation principles: role in the management of postoperative pain and arthritic disorders.

@article{Larsen2008IntraarticularDF,
  title={Intra-articular depot formulation principles: role in the management of postoperative pain and arthritic disorders.},
  author={Claus Selch Larsen and Jesper Ostergaard and Susan Weng Larsen and Henrik Elvang Jensen and Stine Jacobsen and Casper Lindegaard and Pia Haubro Andersen},
  journal={Journal of pharmaceutical sciences},
  year={2008},
  volume={97 11},
  pages={4622-54}
}
The joint cavity constitutes a discrete anatomical compartment that allows for local drug action after intra-articular injection. Drug delivery systems providing local prolonged drug action are warranted in the management of postoperative pain and not least arthritic disorders such as osteoarthritis. The present review surveys various themes related to the accomplishment of the correct timing of the events leading to optimal drug action in the joint space over a desired time period. This… CONTINUE READING