Intra-articular delivery of a herpes simplex virus IL-1Ra gene vector reduces inflammation in a rabbit model of arthritis

@article{Oligino1999IntraarticularDO,
  title={Intra-articular delivery of a herpes simplex virus IL-1Ra gene vector reduces inflammation in a rabbit model of arthritis},
  author={Thomas J Oligino and Steven C. Ghivizzani and Darren P Wolfe and Eric R. Lechman and D Krisky and Zhibao Mi and Christopher H. Evans and Paul D. Robbins and Joseph Charles Glorioso},
  journal={Gene Therapy},
  year={1999},
  volume={6},
  pages={1713-1720}
}
To evaluate the use of HSV-based vectors for arthritis gene therapy we have constructed a first-generation, ICP4 deficient, replication defective herpes simplex virus (HSV) vector (S/0−) and a second-generation HSV vector derivative (T/0−) deficient for the immediate–early genes ICP4, 22 and 27, each carrying a soluble TNF receptor or IL-1 receptor antagonist transgene cassette. A rabbit synovial-fibroblast line in culture, infected by either vector enabled high-level expression of the… CONTINUE READING
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Gene therapy for rheumatic diseases

  • CH Evans
  • Rheum Dis
  • 1998

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