Intra-articular corticosteroid for knee osteoarthritis.

  title={Intra-articular corticosteroid for knee osteoarthritis.},
  author={Peter J{\"u}ni and Roman Hari and Anne W.S. Rutjes and Roland Fischer and Maria Giuseppina Silletta and Stephan Reichenbach and Bruno R. da Costa},
  journal={The Cochrane database of systematic reviews},
BACKGROUND Knee osteoarthritis is a leading cause of chronic pain, disability, and decreased quality of life. Despite the long-standing use of intra-articular corticosteroids, there is an ongoing debate about their benefits and safety. This is an update of a Cochrane review first published in 2005. OBJECTIVES To determine the benefits and harms of intra-articular corticosteroids compared with sham or no intervention in people with knee osteoarthritis in terms of pain, physical function… 
Efficacy of corticosteroids for hand osteoarthritis - a systematic review and meta-analysis of randomized controlled trials
There was low-certainty evidence for a medium effect of oral corticosteroids on pain relief and stiffness improvement and small-to-medium effect on functional improvement at 4-6 weeks, with no significant effect for intra-articular corticosterone.
The Magnitude and Duration of the Effect of Intra-articular Corticosteroid Injections on Pain Severity in Knee Osteoarthritis
The intra-articular corticosteroid had a mild to moderate effect on pain severity up to 3 mos after the injection—much longer than it had previously been reported.
Efficacy and safety of intra-articular therapies in rheumatic and musculoskeletal diseases: an overview of systematic reviews
It is underlined that most IAT currently used in KOA, HOA, and SC exert small effects and are well tolerated, however, no firm conclusions can be drawn for inflammatory arthritis due to the limited data found.
Conservative treatment of knee osteoarthritis.
This work reviewed the different published guidelines, proposing combinations of weight reduction, physical therapy and rehabilitation, self-management education programs and pharmacological treatment for knee osteoarthritis.
Cochrane in CORR®: Intra-articular Corticosteroid For Knee Osteoarthritis.
This CochraneReview of randomized or quasi-randomized control trials evaluated the benefits and harms of intraarticular corticosteroids compared with sham or no intervention in people with knee OA in terms of pain, physical function, quality of life, and safety.
The effectiveness of prolotherapy in treating knee osteoarthritis in adults: a systematic review
Moderate evidence suggests that prolotherapy is safe and can help achieve significant symptomatic control in individuals with OA, both in the short term and long term.
Efficacy and predictive factors of response to intra-articular corticosteroids in knee osteoarthritis
Based upon the existing data, IACS provides a short-term pain relief in a proportion of patients and is likely to be more effective in subgroups of KOA who display inflammatory phenotype.
Different Intra-articular Injections as Therapy for Hip Osteoarthritis: A Systematic Review and Network Meta-analysis.
  • Zhihu Zhao, Jian-xiong Ma, Xin-long Ma
  • Medicine
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
  • 2020


Joint lavage for osteoarthritis of the knee.
Joint lavage does not result in a relevant benefit for patients with knee osteoarthritis in terms of pain relief or improvement of function, and this variation was likely to be explained by differences in the credibility of control interventions.
Review: intra-articular corticosteroid injections are better than placebo for improving symptoms of knee osteoarthritis
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 Q In patients with osteoarthritis
Therapeutic ultrasound for osteoarthritis of the knee or hip.
The results suggest that therapeutic ultrasound may be beneficial for patients with osteoarthritis of the knee, but it is uncertain about the magnitude of the effects on pain relief and function.
Corticosteroid injections for osteoarthritis of the knee: meta-analysis
Evidence supports short term (up to two weeks) improvement in symptoms of osteoarthritis of the knee after intra-articular corticosteroid injection.
Oral or transdermal opioids for osteoarthritis of the knee or hip.
Opioids were more beneficial in pain reduction than control interventions and improvement of function was larger in opioid-treated participants compared with control groups, and risk ratios for safety outcomes were larger.
The Efficacy and Duration of Intra‐articular Corticosteroid Injection for Knee Osteoarthritis: A Systematic Review of Level I Studies
It is concluded that intra‐articular corticosteroids reduce knee pain for at least 1 week and that intraarticular Corticosteroid injection is a short‐term treatment of a chronic problem.
Intra-articular hyaluronic acid and corticosteroids in the treatment of knee osteoarthritis: A meta-analysis
A meta-analysis highlights a therapeutic trajectory for intra-articular HA in knee OA pain, as compared with CS, over six months post-intervention; however, in the long term, HA was found to have an enhanced effect.
Intra-articular and soft tissue injections, a systematic review of relative efficacy of various corticosteroids
There is paucity of data regarding comparative efficacy of various CS injections, and limited number of studies favored TH over other CS (TA, MP, BM).
Predictors of response to intra-articular steroid injections in knee osteoarthritis—a systematic review
Data from individual publications suggest that the presence of effusion, withdrawal of fluid from the knee, severity of disease, absence of synovitis, injection delivery under US guidance and greater symptoms at baseline may all improve the likelihood of response to IASI.