Intra-articular administration of an antibody against CSF-1 receptor reduces pain-related behaviors and inflammation in CFA-induced knee arthritis.

@article{AlvaradoVzquez2015IntraarticularAO,
  title={Intra-articular administration of an antibody against CSF-1 receptor reduces pain-related behaviors and inflammation in CFA-induced knee arthritis.},
  author={Perla Abigail Alvarado-V{\'a}zquez and Carlos Eduardo Morado-Urbina and Gabriela Casta{\~n}eda-Corral and R I Acosta-Gonzalez and Hideki Kitaura and Keisuke Kimura and Teruko Takano-Yamamoto and Juan Miguel Jim{\'e}nez-Andrade},
  journal={Neuroscience letters},
  year={2015},
  volume={584},
  pages={39-44}
}
Several studies have shown that blockade of colony stimulating factor-1 (CSF-1) or its receptor (CSF-1R) inhibits disease progression in rodent models of rheumatoid arthritis (RA); however, the role of the CSF-1/CSF-1R pathway in RA-induced pain and functional deficits has not been studied. Thus, we examined the effect of chronic intra-articular administration of a monoclonal anti-CSF-1R antibody (AFS98) on spontaneous pain, knee edema and functional disabilities in mice with arthritis… CONTINUE READING