Intra-articular IL-10 gene transfer regulates the expression of collagen-induced arthritis (CIA) in the knee and ipsilateral paw.

@article{Lubberts2000IntraarticularIG,
  title={Intra-articular IL-10 gene transfer regulates the expression of collagen-induced arthritis (CIA) in the knee and ipsilateral paw.},
  author={Erik Lubberts and Leo A. B. Joosten and Liduine A M van den Bersselaar and Monique M. A. Helsen and Andrew C. Bakker and Zhou Xing and Carl D Richards and Wim B. van den Berg},
  journal={Clinical and experimental immunology},
  year={2000},
  volume={120 2},
  pages={375-83}
}
We studied the effects of local IL-10 application, introduced by a recombinant human type 5 adenovirus vector, in the mouse knee joint during the early phase of CIA. One intra-articular injection with the IL-10-expressing virus (Ad5E1mIL-10) caused substantial over-expression of IL-10 in the mouse knee joint, using virus dosages which did not induce distracting inflammation. High expression of IL-10 was noted for a few days, being maximal at day 1. One intra-articular injection of Ad5E1mIL-10… CONTINUE READING

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