Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2.

@article{Wang2017IntraarticularDO,
  title={Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2.},
  author={H. Wang and H. Zhang and Q. Sun and Y. Wang and J. Yang and T. Zhang and S. Luo and L. Wang and Y. Jiang and C. Zeng and D. Cai and X. Bai},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2017},
  volume={25 3},
  pages={
          715-727
        }
}
  • H. Wang, H. Zhang, +10 authors X. Bai
  • Published 2017
  • Medicine
  • Molecular therapy : the journal of the American Society of Gene Therapy
MicroRNAs (miRNAs) are emerging as important regulators in osteoarthritis (OA) pathogenesis. In our study, a real-time PCR assay revealed that miR-483-5p was upregulated in articular cartilage from OA patients and experimental OA mice induced by destabilization of the medial meniscus compared to their controls. Overexpression of miR-483-5p by intra-articular injection of lentivirus LV3-miR-483-5p significantly enhanced the severity of experimental OA. Consequently, we synthesized antago-miR-483… Expand
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