Intra-arterial urokinase for acute ischemic stroke: factors associated with complications.

@article{Tirschwell2001IntraarterialUF,
  title={Intra-arterial urokinase for acute ischemic stroke: factors associated with complications.},
  author={David L. Tirschwell and William M Coplin and Kyra J. Becker and P F Vogelzang and Joseph Eskridge and David Haynor and W. Cohen and David W. Newell and H. Richard Winn and William T. Longstreth},
  journal={Neurology},
  year={2001},
  volume={57 6},
  pages={1100-3}
}
The authors abstracted the records of 43 patients treated with intra-arterial urokinase for acute ischemic stroke to identify predictors of serious complications. Sixteen (37%) had such a complication. Higher urokinase dose (>1.5 x 10(6) U), higher mean arterial blood pressure before treatment (>130 mm Hg), basilar occlusive strokes, and severe strokes were most predictive of these complications. Although urokinase is no longer manufactured, these findings identify patients at risk for… CONTINUE READING